Human chorionic gonadotropin is a glycoprotein produced by the trophoblastic cells of the placenta generally 10 to 12 days after conception, Its principle function is to stimulate the corpus luteum to continuously
produce progesterone which stimulates the secretory differentiation of the endometrium.
Chorionic Gonadotropin belongs to a family of glycoproteins that includes luteinizing hormone, follicle stimulating hormone and the pituitary thyrostimulating hormone. Each one of these hormones consists of two chains denominated a and ß. The a chain is the same in the 4 hormones but each one differs in its ß chain.
Histosonda Chorionic Gonadotropin ß Subunit consists of a fragment of single stranded DNA of 278 nucleotides that is targeted against the ß chain of human chorionic gonadotropin RNA.
There are antibodies against the ß subunit of chorionic gonadotropin but they generally produce a strong tissular background that makes the histological interpretation difficult.
The germinal tumors of the gonads and the midline can demonstrate distinct differentiation levels that are difficult to interpret with conventional histological techniques. Histosonda® Chorionic Gonadotropin ß Subunit permits the detection and localization of cells that produce comparable CGB hormone levels in choriocarcinomas as in germinal gonad and midline tumors.
Intended for research use only (RUO).